--- title: Marijuana Use Tied to Increased Risk for Myocardial Infarction in People Aged 50 Years and Younger description: Study links marijuana use to higher risk of heart attack and stroke in adults under 50, highlighting the need for increased awareness of cardiovascular risks. image: https://420intel.com/hubfs/AI-Generated%20Media/Images/The%20image%20depicts%20a%20somber%20medical%20illustration%20featuring%20a%20human%20heart%20intricately%20detailed%20to%20showcase%20its%20anatomy%20Surrounding%20the%20heart%20are%20ominous%20symbols%20representing%20various%20cardiovascular%20risks%20such%20as%20a%20warning%20sign%20for%20myocardial%20infarction-1.jpeg --- [![420intel.com](https://420intel.com/hs-fs/hubfs/Asset%2016-1.png?width=300&height=162&name=Asset%2016-1.png "420intel.com")](https://420intel.com) - [Home](https://420intel.com) - [Advertise](https://420intel.com/advertise) - [Directory](https://420intel.com/directory) - [Topics](https://420intel.com/blog) - [Recreational News](https://420intel.com/blog/tag/recreational-cannabis-news) - [Business News](https://420intel.com/tag/cannabis-business-news) - [Politics](https://420intel.com/tag/cannabis-politics) - [Technology](https://420intel.com/tag/cannabis-technology-news) - [Research](https://420intel.com/tag/medical-cannabis-news) - [Contact](https://420intel.com/contact-us) - [Follow us on Facebook](https://www.facebook.com/420intel) - [Follow us on LinkedIn](https://www.linkedin.com/company/420-intel/) - [Follow us on Twitter](https://x.com/420intel) - [Follow us on Instagram](https://www.instagram.com/420intel) ### Press ESC to close [![420intel.com](https://420intel.com/hs-fs/hubfs/Asset%2016-1.png?width=300&height=162&name=Asset%2016-1.png "420intel.com")](https://420intel.com) - [Home](https://420intel.com) - [Advertise](https://420intel.com/advertise) - [Directory](https://420intel.com/directory) - [Topics](https://420intel.com/blog) - [Recreational News](https://420intel.com/blog/tag/recreational-cannabis-news) - [Business News](https://420intel.com/tag/cannabis-business-news) - [Politics](https://420intel.com/tag/cannabis-politics) - [Technology](https://420intel.com/tag/cannabis-technology-news) - [Research](https://420intel.com/tag/medical-cannabis-news) - [Contact](https://420intel.com/contact-us) - [Follow us on Facebook](https://www.facebook.com/420intel) - [Follow us on LinkedIn](https://www.linkedin.com/company/420-intel/) - [Follow us on Twitter](https://x.com/420intel) - [Follow us on Instagram](https://www.instagram.com/420intel) # Marijuana Use Tied to Increased Risk for Myocardial Infarction in People Aged 50 Years and Younger - [![Buzz](https://420intel.com/hs-fs/hubfs/Buzz-No%20Outline-2.png?width=80&height=80&name=Buzz-No%20Outline-2.png) Buzz](https://420intel.com/blog/author/buzz) - [Medical Cannabis News](https://420intel.com/blog/tag/medical-cannabis-news) - 25 March 2025 People aged 50 years and younger who use **marijuana** are more vulnerable to experiencing adverse cardiovascular events compared with nonusers, according to the results of a new large multicenter retrospective study published in *JACC: Advances.* “This analysis provides evidence linking cannabis-use to adverse cardiovascular events, including MI, ischemic stroke, **HF** and mortality. Notably, cannabis use appears to pose a substantial and independent risk for these outcomes, even in a population without traditional cardiovascular risk factors,” lead author Ibrahim Kamel, MD, from the Boston University School of Medicine, and colleagues reported in their paper published online on March 18, 2025.1 Kamel is also presenting a meta-analysis on **cannabis** and acute MI risk at next week’s upcoming American College of Cardiology 2025 Scientific Session. Marijuana use has become increasingly popular in the US. Currently, medical marijuana is legal in 39 US states, 3 territories, and the District of Columbia, and recreational marijuana use is legal in 24 states and the District of Columbia.2 “While it has therapeutic benefits, cannabis consumption has been linked to adverse cardiovascular outcomes, especially **myocardial infarction** (MI),” Kamel and colleagues wrote. To evaluate the potential cardiovascular risks associated with cannabis use, investigators utilized deidentified electronic medical records from the TriNetX health research network, examining adults aged 50 years or younger between 2010 and 2018. The study included 93 267 cannabis users and 4 543 361 non-users, with a propensity score matching process ensuring balanced baseline characteristics between the groups. The analysis focused on individuals without pre-existing conditions such as **hypertension**, diabetes, hyperlipidemia, or tobacco use to isolate cannabis use as a potential risk factor. Researchers observed that cannabis users had a more than sixfold increased risk of MI (risk ratio \[RR\]: 6.185; 95% CI: 4.892-7.82) compared to non-users. The risk of ischemic **stroke** was also significantly elevated (RR: 4.333; 95% CI: 3.419-5.493). Additionally, cannabis users faced a 3.24 times greater risk of experiencing **major adverse cardiovascular events (MACE)**, which included ischemic stroke, coronary revascularization, and ventricular arrhythmia. The findings underscore the need for increased awareness among clinicians and public health officials regarding the cardiovascular risks associated with cannabis use. As cannabis legalization expands globally, its potential health implications warrant closer scrutiny to guide risk assessment and patient education strategies. “Asking about cannabis use should be part of clinicians’ workup to understand patients’ overall cardiovascular risk, similar to asking about smoking cigarettes,” Kamel said in a press release.3 “At a policy level, a fair warning should be made so that the people who are consuming cannabis know that there are risks.” Despite the compelling associations observed, the study has limitations, including a lack of detailed data on cannabis consumption patterns, dosage, and method of use. Additionally, electronic medical records may contain inconsistencies in self-reported cannabis use.1 “This study has limitations due to lack of detailed cannabis consumption data and potential misclassification. Future research should investigate the dose-response relationship and the effects of **synthetic cannabinoids**,” the research team noted.     [by Patient Care Online](https://www.patientcareonline.com/view/marijuana-use-tied-to-increased-risk-for-myocardial-infarction-in-people-aged-50-years-and-younger?utm_source=www.patientcareonline.com&utm_medium=relatedContent)   [Medical Cannabis News](https://420intel.com/blog/tag/medical-cannabis-news) ![Buzz](https://420intel.com/hs-fs/hubfs/Buzz-No%20Outline-2.png?width=200&height=200&name=Buzz-No%20Outline-2.png) #### [Buzz](https://420intel.com/blog/author/buzz) At 420 Intel, we cover cannabis legalization news throughout the world, offer reliable information for cannabis business owners, detail technological advances that impact the marijuana industry, cover marijuana rallies from across the globe, and everything in between. - - - [Medical Cannabis News](https://420intel.com/blog/tag/medical-cannabis-news) [![Yes, physicians warn, cannabis is bad for the heart](https://420intel.com/hs-fs/hubfs/AI-Generated%20Media/Images/cannabis%20causing%20heart%20failure.jpeg?width=550&height=395&name=cannabis%20causing%20heart%20failure.jpeg)](https://420intel.com/blog/yes-physicians-warn-cannabis-is-bad-for-the-heart) - [![Buzz](https://420intel.com/hs-fs/hubfs/Buzz-No%20Outline-2.png?width=80&height=80&name=Buzz-No%20Outline-2.png) Buzz](https://420intel.com/blog/author/buzz) - 28 January 2025 #### [Yes, physicians warn, cannabis is bad for the heart](https://420intel.com/blog/yes-physicians-warn-cannabis-is-bad-for-the-heart) Cannabis use is on the rise throughout the United States, but it is not as harmless as some people... [Medical Cannabis News](https://420intel.com/blog/tag/medical-cannabis-news) [![Study reveals potential link between cannabis use and psychosis](https://420intel.com/hs-fs/hubfs/AI-Generated%20Media/Images/The%20image%20depicts%20a%20closeup%20view%20of%20a%20brain%20scan%20highlighting%20areas%20of%20neuromelanin%20accumulation%20Dark%20black%20spots%20are%20prominently%20visible%20in%20the%20midbrain%20regions%20specifically%20the%20substantia%20nigra%20and%20ventral%20tegmental%20areas%20indicating%20heightened%20dopa-1.jpeg?width=550&height=395&name=The%20image%20depicts%20a%20closeup%20view%20of%20a%20brain%20scan%20highlighting%20areas%20of%20neuromelanin%20accumulation%20Dark%20black%20spots%20are%20prominently%20visible%20in%20the%20midbrain%20regions%20specifically%20the%20substantia%20nigra%20and%20ventral%20tegmental%20areas%20indicating%20heightened%20dopa-1.jpeg)](https://420intel.com/blog/study-reveals-potential-link-between-cannabis-use-and-psychosis) - [![Buzz](https://420intel.com/hs-fs/hubfs/Buzz-No%20Outline-2.png?width=80&height=80&name=Buzz-No%20Outline-2.png) Buzz](https://420intel.com/blog/author/buzz) - 10 April 2025 #### [Study reveals potential link between cannabis use and psychosis](https://420intel.com/blog/study-reveals-potential-link-between-cannabis-use-and-psychosis) Although it's been six years since cannabis was legalized in Canada, further research is needed to... [Recreational Cannabis News](https://420intel.com/blog/tag/recreational-cannabis-news) [![Cannabis use disorder linked to increased cardiovascular disease risk](https://420intel.com/hs-fs/hubfs/Imported_Blog_Media/Cannabis%20use%20disorder%20linked%20to%20increased%20cardiovascular%20disease%20risk.jpg?width=550&height=395&name=Cannabis%20use%20disorder%20linked%20to%20increased%20cardiovascular%20disease%20risk.jpg)](https://420intel.com/blog/cannabis-use-disorder-linked-increased-cardiovascular-disease-risk) - [Admin](https://420intel.com/blog/author/admin) - 7 March 2024 #### [Cannabis use disorder linked to increased cardiovascular disease risk](https://420intel.com/blog/cannabis-use-disorder-linked-increased-cardiovascular-disease-risk) ## Study Highlights a 60% Increased Cardiovascular Disease Risk in Individuals with Cannabis Use... - [Follow us on Facebook](https://www.facebook.com/420intel) - [Follow us on LinkedIn](https://www.linkedin.com/420intel) - [Follow us on Twitter](https://twitter.com/420intel) - [Follow us on Instagram](https://www.instagram.com/420intel) Back to Top ```json { "@context" : "https://schema.org", "@type" : "BlogPosting", "author" : { "@type" : "Person", "name" : "Buzz", "url" : "https://420intel.com/blog/author/buzz" }, "dateModified" : "2025-03-25T10:55:58.162Z", "datePublished" : "2025-03-25T10:55:58.000Z", "headline" : "Marijuana Use Tied to Increased Risk for Myocardial Infarction in People Aged 50 Years and Younger", "image" : [ "https://420intel.com/hubfs/AI-Generated%20Media/Images/The%20image%20depicts%20a%20somber%20medical%20illustration%20featuring%20a%20human%20heart%20intricately%20detailed%20to%20showcase%20its%20anatomy%20Surrounding%20the%20heart%20are%20ominous%20symbols%20representing%20various%20cardiovascular%20risks%20such%20as%20a%20warning%20sign%20for%20myocardial%20infarction-1.jpeg" ], "mainEntityOfPage" : { "@id" : "https://420intel.com/blog/marijuana-use-tied-to-increased-risk-for-myocardial-infarction-in-people-aged-50-years-and-younger", "@type" : "WebPage" }, "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "https://420intel.com/hubfs/Asset%2016.png" }, "name" : "420 Intel" } } ```